SubtiBank SubtiBank
yaaH [2017-8-11 16:0:3]
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yaaH [2017-8-11 16:0:3]

general stress protein, survival of ethanol stress, [protein|CEBEC9CECCF445C40D793E61A2CD23175631A473|SafA]-dependent protein of the inner spore coat, spore cortex lytic protein
locus
BSU00160
pI
5.62
mw
48.47 kDa
protein length
427 aa Sequence Blast
gene length
1281 bp Sequence Blast
function
survival of ethanol stress, protection of the spore
product
N-acetylglucosaminidase
essential
no
synonyms
sleL
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.1|Class I]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]

    • Gene

    Coordinates
    23,868 → 25,151

    The protein

    Paralogous protein(s)

  • [protein|DFA0BFED9FC2C47ABAA2284514CE2F81BD9EDFEF|YdhD]

    • [SW|Domains]

  • contains two N-acetylglucosamine-polymer-binding [SW|LysM domain]s at the N-terminus [Pubmed|18430080]
  • [SW|glycoside hydrolase family 18 domain] (aa 125 to 410)

    • Structure

  • [PDB|4S3K] (SleL from B. megaterium, 55% identity) [pubmed|26190134]

    • [SW|Localization]

  • inner spore coat, localization depends on [protein|CEBEC9CECCF445C40D793E61A2CD23175631A473|SafA] [Pubmed|19933362,22171814]

    • Additional information

  • required for survival of ethanol stress [Pubmed|15805528]

    • Expression and Regulation

    Operons

    genes
    [gene|77BEC74867422AA225A1F12AD63464656DBDCBE8|yaaH]
    description
    [Pubmed|10419957]

    sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|15699190,10419957], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]
  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|15805528], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

    • regulatory mechanism

  • [protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID]: repression, [Pubmed|15383836], in [regulon|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID regulon]

    • regulation

  • expressed during sporulation in the mother cell ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|15383836,10419957]

    • additional information

  • the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
    • view in new tab

    genes
    [gene|95C78F511C49E04241D31593E6837BDFF48D6E14|yaaI]-[gene|77BEC74867422AA225A1F12AD63464656DBDCBE8|yaaH]
    description
    [pubmed|22383849]

    sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|15805528], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

    • regulation

  • induced by stress ([protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]) [Pubmed|15805528]
    • view in new tab

    Biological materials

    Mutant

  • MGNA-B889 (yaaH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1888 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 18430080,23202530

    • Original publications

  • 19087206,12884008,10419957,15805528,11964120,19933362,22171814,15383836,22343356,18835992,26190134